Set in the weeks following Resistance: Fall of Man, Resistance: Retribution follows the story of former British Marine James Grayson.
After a personal tragedy, he is forced to kill his own brother inside a Chimeran conversion center. Grayson embarks on a vendetta to destroy every conversion center he can find.
Eventually, Grayson learns that his efforts have been futile. In Western Europe, the Chimerans have developed a new method of converting humans into aliens.
The European resistance - the Maquis - requests Grayson's help, and he joins Cartwright and Parker in Operation Overstrike.
The war to reclaim the European continent has begun.